What is PQQ?

PQQ, or pyrroloquinoline quinone, is a chemical substance from the quinone group. It was discovered in humans just over 20 years ago. It acts as a cofactor for oxidative enzymes. Cofactors are molecules needed by enzymes to catalyze chemical reactions. In short, without cofactors, enzymes are incomplete.

PQQ supports the functioning of mitochondria and the synthesis of ATP in the body's cells. Additionally, it has the ability to participate in redox (oxidation-reduction) reactions, making it an excellent antioxidant that helps protect against the negative effects of oxidative stress [1-2].

PQQ – Action

PQQ affects cellular mitochondria in several ways. First, it supports the enzymatic processes related to ATP production, which is the substance from which cells derive energy. Second, it can contribute to the optimization of mitochondrial biogenesis. PQQ also acts as an antioxidant, helping to protect cells from damage caused by oxidation processes, particularly affecting mitochondria [1,3-5].

Cells with high energy demands have the most mitochondria. These include brain cells – neurons. Studies suggest that PQQ may improve concentration, memory, and cognitive functions, as well as prevent neurodegenerative diseases. Furthermore, it supports lipid metabolism and increases insulin sensitivity, which can also aid in energy management in the body [1-2,6-8].

A scientific study conducted on a group of adult Japanese individuals showed that PQQ may lower blood triglyceride levels and thus influence cholesterol levels. Combined with other scientific evidence suggesting that this compound may lower blood pressure, PQQ also supports cardiovascular health [2,9].

Want to see how PQQ can support your body? Try the proven dietary supplement PQQ 20 mg from Osavi.

What is Coenzyme Q10?

Coenzyme Q10, also known as CoQ10 or ubiquinone, is another cofactor for enzymes that is responsible for cellular respiration processes and ATP production. This makes it a compound that provides energy and vitality to cells.

CoQ10 can also act as an antioxidant, as it participates in redox reactions, similar to PQQ. As a component of the electron transport chain in mitochondria, it is crucial for the proper functioning of all cells in the body, especially those with high energy demands [10-12].

Coenzyme Q10 – Properties

A meta-analysis conducted by researchers in 2022 showed that due to its antioxidant properties and its influence on energy production in cells, coenzyme Q10 can reduce feelings of fatigue [12].

CoQ10 is also known for its properties that support cardiovascular health. It lowers lipid peroxidation levels, improves blood flow, and protects blood vessels [1,13-14].

If you dream of a boost of energy and vitality even on cloudy days, try the combination of vitamins and coenzyme Q10 in the form of the dietary supplement Multivitamin, Coenzyme Q10 in spray form.

The Combined Power of the Best Ingredients for the Nervous System

Coenzyme Q10 is an essential component for the energy production process in cellular mitochondria.

What if we combined it with vitamins B6 and B12 and Cognizin® citicoline?

Vitamins B6 and B12 are known for their beneficial effects on the nervous system:

• they support its proper functioning,
• they support psychological functions,
• they reduce feelings of fatigue and tiredness.

Citicoline is a precursor to phosphatidylcholine, which is a component of the membranes of nervous system cells.

The combination of coenzyme Q10, B vitamins, citicoline, and L-theanine creates an optimal set of substances for comprehensive support of your attention, concentration, and memory, as well as reducing feelings of fatigue.

If you want to benefit from the combined power of these ingredients, reach for the dietary supplement Neuropower with Citicoline 250 mg from Osavi.

Sources:

1. Jonscher, Karen R., et al. “Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention.” Biomolecules, vol. 11, no. 10, September 2021, p. 1441. PubMed Central, https://doi.org/10.3390/biom11101441.
2. Yan, Tingdong, et al. “Pyrroloquinoline Quinone (PQQ): Its impact on human health and potential benefits: PQQ: Human health impacts and benefits.” Current Research in Food Science, vol. 9, January 2024, p. 100889. ScienceDirect, https://doi.org/10.1016/j.crfs.2024.100889.
3. He, Kai, et al. “Antioxidant and Pro-Oxidant Properties of Pyrroloquinoline Quinone (PQQ): Implications for Its Function in Biological Systems.” Biochemical Pharmacology, vol. 65, no. 1, January 2003, pp. 67–74. PubMed, https://doi.org/10.1016/s0006-2952(02)01453-3.
4. Nalbant, Muhammed Ali, and Onur Eroğlu. “Effects of Pyrroloquinoline Quinone (PQQ) and Coenzyme Q10 on Mitochondrial Genes, MitomiRs and Cellular Properties in HepG2 Cell Line.” Cellular and Molecular Biology, vol. 69, no. 4, April 2023, pp. 60–69. cellmolbiol.org, https://doi.org/10.14715/cmb/2023.69.4.9.
5. Harris, Calliandra B., et al. “Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects.” The Journal of Nutritional Biochemistry, vol. 24, no. 12, December 2013, pp. 2076–84. ScienceDirect, https://doi.org/10.1016/j.jnutbio.2013.07.008.
6. Shiojima, Yoshiaki, et al. “Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study.” Journal of the American Nutrition Association, vol. 41, no. 8, 2022, pp. 796–809. PubMed,